Research progress on the mechanism of role of podoplanin in sepsis

VernacularTitle:平足蛋白在脓毒症中作用机制的研究进展
Author: Zhiyuan ZHANG ¹ ; Jing YU ; Nan ZHANG ; Zongmei WEN
Author Information

1. 同济大学附属上海市肺科医院麻醉科，上海　200433
Keywords: Podoplanin; C-type lectin-like receptor 2; Sepsis
From: Chinese Critical Care Medicine 2022;34(9):991-994
CountryChina
Language:Chinese
Abstract: Podoplanin (PDPN) is a small transmembrane mucin-like glycoprotein which is expressed on the surface of lymphatic endothelial cells, glomerular podocytes, type-Ⅰ alveolar epithelial cells and some tumor cells. PDPN plays crucial function in variety of physiological and pathological processes such as embryonic development, immunoreaction, inflammation and cancer. C-type lectin-like receptor 2 (CLEC2) is mainly expressed on the platelet which specific ligand is PDPN. The interaction between PDPN and CLEC2 has received extensive attention. In this review, we summarized recent researches on the role of in sepsis and elaborated the possible mechanisms and some potential therapies for sepsis by targeting PDPN, which may provide theoretical basis for the mechanism and treatment of sepsis.