Research progress of phosphoglycerate mutase 5-mediated mitophagy and necroptosis
10.3760/cma.j.cn121430-20220428-00431
- VernacularTitle:磷酸甘油酸变位酶5介导线粒体自噬与坏死性凋亡的研究进展
- Author:
Jing ZHANG
1
;
Miao CHEN
;
Xinxin LIU
;
Yingcong REN
;
Guoyue LIU
;
Song QIN
Author Information
1. 遵义医科大学附属医院重症医学科，贵州遵义 563000
- Keywords:
Phosphoglycerate mutase 5;
Dynamin-related protein 1;
Mitophagy;
Necroptosis
- From:
Chinese Critical Care Medicine
2022;34(8):890-896
- CountryChina
- Language:Chinese
-
Abstract:
Mitophagy is the selective degradation of damaged mitochondria, and it is of great significance to maintain the normal quantity and quality of mitochondria to ensure cell homeostasis and survival. Necroptosis is a type of programmed cell necrosis that can be induced by excessive mitophagy. Reactive oxygen species (ROS) are produced mainly by mitochondria and can damage mitochondria. Hyperoxic acute lung injury (HALI) is a serious complication of clinical oxygen therapy, and its pathogenesis is not clear. Existing studies have shown that mitophagy and necroptosis are involved in the occurrence of HALI. There are many mechanisms regulating mitophagy and necroptosis, including tumor necrosis factor-α (TNF-α), E3 ubiquitin protein ligase (PINK1/Parkin) protein pathway encoded by PTEN-induced kinase 1/PARK2 gene, phosphoglycerate mutase 5 (PGAM5), etc. PGAM5 has been proved to be a key factor linking mitophagy and necroptosis. Previous studies of our team found that the mechanism of microRNA-21-5p (miR-21-5p) alleviating HALI was related to its pGAM5-mediated inhibition of mitophagy, but the mechanism of PGAM5-mediated mitophagy and necroptosis remains unclear. Therefore, this paper reviews the targets of PGAM5-mediated mitophagy and necroptosis, in order to find clues of lung protection of pGAM5-mediated mitophagy and necroptosis in HALI, and provide theoretical basis for subsequent basic research.
