Research progress on molecular mechanism of transcription factor C/EBPβ in lung diseases
10.3760/cma.j.cn121430-20220809-00731
- VernacularTitle:转录因子C/EBPβ在肺部疾病中的分子机制研究进展
- Author:
Haiyun WEN
1
;
Yalan LUO
;
Peng GE
;
Bowen LAN
;
Xuanchi DONG
;
Guixin ZHANG
;
Hailong CHEN
Author Information
1. 大连医科大学附属第一医院腹部急症外科，辽宁大连 116011
- Keywords:
CCAAT enhancer binding protein β;
Lung injury;
Inflammation;
Cancer;
Transcription regulation
- From:
Chinese Critical Care Medicine
2022;34(8):875-880
- CountryChina
- Language:Chinese
-
Abstract:
CCAAT enhancer binding protein β (C/EBPβ), as a nuclear transcription factor necessary for the development of liver, airway epithelium, and adipose tissue, plays a vital role in physiological processes related to cell proliferation, apoptosis, and differentiation. However, the up-regulation of C/EBPβ activates signal pathways related to inflammatory response, epithelial-mesenchymal transition, cell proliferation and invasion, immune response, and angiogenesis by regulating a series of downstream genes transcription promotes the development of lung diseases. Therefore, targeting C/EBPβ may be a potential treatment strategy for lung diseases. This paper summarizes the regulatory effects of C/EBPβ and related signaling pathways in lung infection, asthma, chronic obstructive pulmonary disease, lung injury, pulmonary fibrosis, and lung cancer to provide a theoretical basis for the precision medicine of lung diseases.
