Research progress on the role of endothelial cell-specific molecular-1 in acute respiratory distress syndrome
10.3760/cma.j.cn121430-20210409-00534
- VernacularTitle:内皮细胞特异性分子-1在急性呼吸窘迫综合征中的作用研究进展
- Author:
Yiru YE
1
;
Shanshan SU
;
Ying ZHOU
;
Yongqin YAN
;
Yuping LI
Author Information
1. 温州医科大学附属第一医院呼吸与危重症医学科，浙江温州 325000
- Keywords:
Acute respiratory distress syndrome;
Endothelial cell-specific molecular-1;
Endocan;
Biomarker
- From:
Chinese Critical Care Medicine
2022;34(7):773-776
- CountryChina
- Language:Chinese
-
Abstract:
Acute respiratory distress syndrome (ARDS), a common respiratory critical illness with multiple causes, is associated with high mortality. The high degree of heterogeneity may be the reason why it is lack of highly specific and sensitive biological biomarkers. Therefore, it is an urgent need to explore biomarkers, perform phenotypic analysis and establish risk stratification model for diagnosis, prognosis, and treatment of ARDS. Endothelial cells specificity molecular-1 (ESM-1, endocan), is a soluble dermatan sulfate proteoglycan, and be involved in regulating biological behaviors such as cell proliferation, differentiation and migration. Numerous studies have confirmed that ESM-1 is closely related to inflammation, endothelial activation and dysfunction. However, the role of ESM-1 in the initiating and developing process of ARDS is still unclear. To provide a scientific basis for its clinical applications in ARDS, such as early prognosis assessment and timely prevent strategies, this paper focuses on the biological properties and the clinical value of ESM-1 as a potential biomarker for ARDS.
