Research advances of myeloid-derived suppressor cells in sepsis-induced immunosuppression
10.3760/cma.j.cn121430-20210930-01432
- VernacularTitle:髓源性抑制细胞导致脓毒症免疫抑制的研究进展
- Author:
Zhekang PENG
1
;
Jiqian XU
;
Yajun HE
;
Deyi SUN
;
You SHANG
Author Information
1. 华中科技大学同济医学院附属协和医院重症医学科，湖北武汉 430022
- Keywords:
Myeloid-derived suppressor cell;
Sepsis;
Immunosuppression
- From:
Chinese Critical Care Medicine
2022;34(6):666-669
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Most patients with sepsis underwent a state of immune suppression after surviving the acute inflammatory response, and were susceptible to secondary nosocomial infections, leading to a prolonged hospitalization and increased mortality rate. Myeloid-derived suppressor cells (MDSCs), a heterogeneous population with immunosuppressive activities, can contribute to the development of immunosuppression in patients with cancer and inhibit the host immune response, but the characteristics of MDSCs and their functional mechanism has not been fully addressed in the development of sepsis-induced immunosuppression. Thus, this review will summary the new findings on the mechanisms of MDSCs in septic immunosuppressionin order to provide ideas and directions for targeting MDSCs as treatment of septic immunosuppression.
