Research progress on the role of connexin 43 phosphorylation and its signal pathway in the pathogenesis of sepsis

VernacularTitle:连接蛋白43磷酸化及其信号通路在脓毒症发生机制中的作用研究进展
Author: Xiwei ZHAO ¹ ; Kai LIU ; Linyi HOU ; Wenkai ZHANG
Author Information

1. 山西医科大学第二附属医院心胸外科，太原　030001
Keywords: Sepsis; Connexin 43; Signal pathway; Pathogenesis
From: Chinese Critical Care Medicine 2022;34(6):655-660
CountryChina
Language:Chinese
Abstract: Sepsis is the main cause of death in intensive care unit (ICU). Sepsis and septic shock seriously affect the prognosis of patients and increase the mortality and re-morbidity of patients. Early and timely intervention can reduce the mortality and recurrence rate of patients with sepsis. The occurrence of sepsis may be related to the phosphorylation of connexin 43 (Cx43), which needs to be realized through various signal pathways. The related sites of connexin 43 are phosphorylated through different signal pathways to achieve the precise regulation of sepsis, these sites may be related targets for the treatment of sepsis and provide a direction for accurate treatment of sepsis. This paper mainly analyzes the role of Cx43-related signal pathways such as protein kinase A (PKA), protein kinase C (PKC), mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) in the pathogenesis of sepsis.