Advance in research on application of endotoxin adsorption membrane in treatment of coronavirus disease 2019
10.3760/cma.j.cn121430-20210803-01120
- VernacularTitle:内毒素吸附膜在治疗新型冠状病毒肺炎中的应用进展
- Author:
Jinliang JIAO
1
;
Abuduaini BUZUKELA
;
Mengchen LI
;
Turdi BAIHETINISHA
Author Information
1. 新疆医科大学第一附属医院呼吸重症监护室，新疆维吾尔自治区乌鲁木齐 830054
- Keywords:
Coronavirus disease 2019;
Cytokine storm;
Endotoxin adsorption
- From:
Chinese Critical Care Medicine
2022;34(5):538-541
- CountryChina
- Language:Chinese
-
Abstract:
The new type coronavirus disease 2019 (COVID-19) is a contagious disease of severe lung inflammation induced by 2019 novel coronavirus (2019-nCoV). The World Health Organization (WHO) nomenclature of the newly discovered coronavirus was 2019-nCoV and the disease caused by 2019-nCoV was named COVID-19 on January 12, 2020. After 2019-nCoV invasion into a human body, it can stimulate the human immune system and engender a large number of cytokines, triggering a cytokine storm, resulting in severe infection, acute lung injury, multiple organ dysfunction, etc. Therefore, theoretically, the removal of over-production of cytokines can avoid the occurrence of cytokine storm and reduce the incidence of severe critical COVID-19 and serious poor prognosis. In this review, the authors systematically reviewed the past published reports related to the occurrence of cytokine storm in sepsis resulting in deterioration of disease situation, and recently they analyzed the therapeutic effects of patients with severe critical COVID-19 using endotoxin adsorption membrane for treatment in the disease course, further providing the effective clinical evidence of applying endotoxin adsorption membrane for treatment of COVID-19.
