Research progress on the relationship between diquat poisoning and nuclear factor E2-related factor 2 signaling pathway
10.3760/cma.j.cn121430-20210816-01185
- VernacularTitle:敌草快中毒与Nrf2信号通路关系的研究进展
- Author:
Jianhong WANG
1
;
Tongying LIU
;
Manhong ZHOU
Author Information
1. 遵义医科大学附属医院急诊科，贵州遵义 563003
- Keywords:
Diquate;
Nuclear factor E2-related factor 2;
Oxidative stress;
Lipid peroxidation;
Reactive oxygen species;
NAD(P)H: quinone oxidoreductase 1
- From:
Chinese Critical Care Medicine
2022;34(4):444-448
- CountryChina
- Language:Chinese
-
Abstract:
Since the production and use of paraquat was banned in China in 2016, the use of diquat (DQ) has been increasing and the clinical cases of DQ poisoning have also shown an increasing trend every year. The treatment of DQ poisoning is a worldwide medical problem, and there is no specific antidote. Studies have found that oxidative stress, lipid peroxidation, neurotoxicity, reproductive and developmental toxicity play an important role in DQ poisoning. Nuclear factor E2-related factor 2 (Nrf2) can inhibit oxidative stress, lipid peroxidation and inflammation by regulating the protein expression of upstream and downstream signaling molecules. Therefore, the role of Nrf2 signaling pathway in the poisoning and treatment of DQ has become a hot spot of attention for emergency critical care researchers in recent years. This paper reviews the relationship between Nrf2 signal pathway and DQ poisoning, in order to provide a theoretical basis for improving the treatment strategy for DQ poisoning.
