Research progress on metabolomics of acute respiratory distress syndrome
10.3760/cma.j.cn121430-20210603-00823
- VernacularTitle:急性呼吸窘迫综合征的代谢组学研究进展
- Author:
Xiaoyuan DUAN
1
;
Wei XU
Author Information
1. 中国医科大学附属盛京医院儿科重症监护病房，辽宁沈阳 110004
- Keywords:
Acute respiratory distress syndrome;
Acute lung injury;
Metabonomics;
Biomarker;
Heterogeneity
- From:
Chinese Critical Care Medicine
2022;34(4):434-439
- CountryChina
- Language:Chinese
-
Abstract:
Acute respiratory distress syndrome (ARDS) is a clinically and biologically heterogeneous disease. Given the heterogeneity of ARDS due to the wide range of etiological, clinical, and molecular manifestations, the current scientific consensus is that ARDS is not a single disease, but rather a set of diseases that require further research to properly classify and identify. Metabonomics, as a rapidly developing field of systems biology, has made many breakthroughs in science and medicine as an interdisciplinary platform. Metabonomics provides an important opportunity for the discovery and analysis of biomarkers in the diagnosis of ARDS, which is expected to reveal the biological process behind ARDS and show great potential in solving the heterogeneity and severity assessment of ARDS. This review focuses on the literature of ARDS metabonomics and summarizes the progress of ARDS metabonomics research and the main obstacles.
