Research progress on the molecular regulatory mechanism of exosome biogenesis

VernacularTitle:外泌体生成调控机制的研究进展
Author: Haizhen DUAN ¹ ; Lu GAN ; Yu CAO
Author Information

1. 四川大学华西医院急诊科，成都　610000
Keywords: Exosome; Extracellular vesicle; Biogenesis
From: Chinese Critical Care Medicine 2022;34(4):429-433
CountryChina
Language:Chinese
Abstract: Exosomes are small vesicles with a diameter of about 40-160 nm actively secreted by cells. They participate in a variety of pathophysiological processes and are closely related to the occurrence and development of diseases. As a newly carrier of intercellular communication and circulating biomarkers of disease diagnosis and prognosis, exosomes have attracted great attention for their potential clinical applications. However, many aspects such as exosome biogenesis, targeted transport, and mechanism of action are still unclear. This paper focuses on the exosome biogenesis, summarizes the exosome biogenesis pathways, and describes relevant molecular modulation mechanisms of importance. And this review provides a theoretical basis for disease treatment based on regulating exosome production.