Correlation between HLA-Cw*0602 and LCE3B_LCE3C-del allele interaction and psoriasis vulgaris in a population of Mongolian nationality in Inner Mongolia
10.3760/cma.j.cn341190-20210821-00977
- VernacularTitle:HLA-Cw*0602和LCE3B_LCE3C-del基因交互作用与内蒙古地区蒙古族人群寻常型银屑病的相关性研究
- Author:
Limin TIAN
1
;
Lizhong LI
;
Yuting CAO
;
Wenchao ZHAO
;
Li SUN
Author Information
1. 内蒙古科技大学包头医学院第一附属医院皮肤科,包头014010
- Keywords:
Psoriasis;
Ethnic groups;
Mongolia;
Heredity;
LCE3B_LCE3C-del;
HLA-Cw*0602
- From:
Chinese Journal of Primary Medicine and Pharmacy
2022;29(12):1818-1821
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of HLA-Cw*0602 and LCE3B_LCE3C-del allele interaction on the risk of psoriasis vulgaris in a population of Mongolian nationality in Inner Mongolia. Methods:A total of 365 Mongolian patients with psoriasis vulgaris who received treatment in The Affiliated Hospital of Inner Mongolia Medical University from January 2006 to December 2015 (case group) and 284 healthy subjects who concurrently received physical examination in the same hospital (control group) were included in this study. After sex and age matching, and quality control, the correlations between HLA-Cw*0602 and LCE3B_LCE3C-del allele and psoriasis vulgaris in a population of Mongolian nationality were analyzed using SPSS 20.0 software. The interaction between HLA-Cw*0602 and LCE3B_LCE3C-del alleles (adjusting for potential confounders including age and sex) was analyzed using logistic regression. Results:Logistic regression interaction item Int of dominant inheritance mode HLA-Cw*0602 allele and recessive inheritance mode LCE3C_LCE3B-del allele revealed OR = 2.38, P = 0.033, and interaction index S = 1.21, indicating that there was a synergistic effect between the two alleles. Conclusion:The co-existence of HLA-Cw*0602 and LCE3B_LCE3C-del may increase the risk of psoriasis vulgaris in a population of Mongolian nationality in Inner Mongolia.
