Antibiotic-loaded bone cement combined with debridement and vacuum sealing drainage for treatment of diabetic foot ulcer wounds
10.3760/cma.j.cn341190-20200722-01268
- VernacularTitle:抗生素骨水泥联合清创+负压封闭引流治疗糖尿病足溃疡创面的效果观察
- Author:
Jingjing BAO
1
;
Xianjun HUANG
;
Lei JIANG
Author Information
1. 浙江省荣军医院手足外科，嘉兴 314000
- Keywords:
Diabetic foot;
Negative-pressure wound therapy;
Negative-pressure;
Drainage;
Anti-bacterial agents;
Bone cements;
Ulcer;
Debridement;
Wound healing;
Length of
- From:
Chinese Journal of Primary Medicine and Pharmacy
2022;29(7):1031-1034
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of antibiotic-loaded bone cement combined with debridement and vacuum sealing drainage in the treatment of diabetic foot ulcer wounds.Methods:Sixty-four patients with diabetic foot ulcers who received treatment in Zhejiang Rongjun Hospital from January 2018 to January 2020 were included in this study. They were randomly assigned to undergo either debridement treatment + vacuum sealing drainage (control group, n = 32) or antibiotic-loaded bone cement + debridement + vacuum sealing drainage (observation group, n = 32). The number of patients positive for bacterial culture at different time points and treatment-related indices were compared between the two groups. Results:At 3, 6 and 9 days after admission, the positive rates of bacterial culture in the observation group were 37.50%, 15.63% and 0.00%, respectively, which were significantly lower than 62.50%, 40.62% and 12.50% in the control group ( χ2 = 4.00, 4.95, 4.27, all P < 0.05). The number of operations in the observation group was significantly lower than that in the control group [(2.96 ± 0.38) vs. (3.63 ± 0.69), t = 4.81, P < 0.001). The length of hospital stay in the observation group was significantly shorter than that in the control group [(34.74 ± 3.03) days vs. (45.18 ± 2.41) days, t = 15.25, P < 0.001). The duration to wound healing in the observation group was significantly shorter than that in the control group [(58.23 ± 10.12) days vs. (72.69 ± 11.21) days, t = 6.06, P < 0.001]. Conclusion:Antibiotic-loaded bone cement combined with debridement and vacuum sealing drainage is effective in the treatment of diabetic foot ulcer. The combined treatment can effectively prevent infection of ulcer wounds, reduce the number of operations, and thereby shorten the length of hospital stay.
