Expression of Cyclooxygenase-2 and Microsomal Prostaglandin E2 Synthase-1 in Human Renal Cell Carcinoma.
- Author:
Young Ha CHO
1
;
Tae Jung JANG
;
Kyung Seop LEE
Author Information
1. Department of Urology, College of Medicine, Dongguk University, Gyeongju, Korea. ksleemd@dongguk.ac.kr
- Publication Type:Original Article
- Keywords:
Renal cell carcinoma;
Cyclooxygenase-2;
mPGES-1
- MeSH:
Blotting, Western;
Carcinogenesis;
Carcinoma, Renal Cell*;
Cyclooxygenase 2*;
Dinoprostone*;
Humans*;
Immunohistochemistry;
Nephrectomy
- From:Korean Journal of Urology
2005;46(10):1057-1063
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: There is ample evidence suggesting an important role for cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in tumorigenesis. This study aimed at evaluating the clinical significance of the expressions of COX-2 and mPGES-1 in the development and progression of human renal cell carcinomas (RCC). MATERIALS AND METHODS: Tumor samples were obtained from 27 RCC patients who had undergone a radical nephrectomy. The expressions of COX-2 and mPGES-1 were evaluated using immunohistochemistry and Western blot analyses. RESULTS: COX-2 and mPGES-1 were expressed in 16 (59.3%) and in 11 (40.7%) of the 27 RCC patients. The expressions of COX-2 and mPGES-1 were correlated with the tumor grade, but not with the pathological stage. Western blot analysis confirmed a higher COX-2 expression in the RCC than non-tumorous tissues, but that of mPGES-1 was similar between the tumorous and non-tumorous portions. CONCLUSIONS: Our results suggest that the expression of COX-2 in RCC patients may be associated with carcinogenesis and; therefore, a useful biomarker in RCC.
