Analysis of serum erythropoietin test results of adult patients with Kaschin-Beck disease in Qinghai Province
10.3760/cma.j.cn231583-20210924-00321
- VernacularTitle:青海省成人大骨节病患者血清EPO检测结果分析
- Author:
Yu SHI
1
;
Qiang LI
;
Xin ZHOU
;
Hongmei XUE
;
Jianling WANG
;
Guanglan PU
;
Cuiling LA
;
Lansheng HU
;
Liqing XU
;
Jiquan LI
;
Zhijun ZHAO
;
Lihua WANG
Author Information
1. 青海大学医学部公共卫生系，西宁 810010
- Keywords:
Erythropoietin;
Adult;
Kaschin-Beck disease;
Qinghai Plateau
- From:
Chinese Journal of Endemiology
2022;41(6):437-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the results of serum erythropoietin (EPO) in adults patients with Kaschin-Beck disease (KBD) in Qinghai Province.Methods:According to the "Diagnosis of Kaschin-Beck Disease" (WS/T 207-2010), by using clinical examination and X-ray, adults over 20 years old in KBD areas of Xinghai County and Guide County, Hainan Tibetan Autonomous Prefecture, Qinghai Province, were divided into KBD case group ( n = 109) and internal control group ( n = 95) in July 2019. At the same time, healthy people were selected as external control group ( n = 90) in Xunhua County. Then 2 ml fasting cubital venous blood was collected from the target population to separate serum. The serum EPO level was determined by enzyme-linked immunosorbent assay (ELISA). Results:There was no significant difference in age and sex ratio among the 3 groups ( F = 0.73, P = 0.484; χ 2 = 1.03, P = 0.611). There was significant difference in serum EPO levels among the 3 groups [KBD case, internal and external control groups: (30.74 ± 26.23), (19.73 ± 11.53) and (10.83 ± 4.48) U/L, F = 26.51, P < 0.001]. Multiple comparisons showed that there were statistically significant differences in serum EPO levels between KBD case group and the internal and external control groups ( P < 0.05), but there was no significant difference between the internal and external control groups ( P > 0.05). Conclusions:The serum EPO level in adult KBD patients in Qinghai Province is increased significantly.
