Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets
- Author:
S.Parimi DIVYA
1
;
Gupta YAMINI
;
Marpu SREEKAR
;
S.Bhatt CHANDRA
;
K.Bollu THARUN
;
K.Suresh ANIL
Author Information
1. Bionanotechnology&Sustainable Laboratory,Department of Biological Sciences,School of Engineering and Applied Sciences,Sri Ramaswamy Memorial(SRM)University,Amaravati,522503,India
- Keywords:
Nanomagnets;
Biomimetics;
Utrasmall-SPIONs;
Magnetization;
Core-fusion;
Cancer theragnostics
- From:
Journal of Pharmaceutical Analysis
2022;12(3):365-379
- CountryChina
- Language:Chinese
-
Abstract:
Cancer therapy is a fast-emerging biomedical paradigm that elevates the diagnostic and therapeutic po-tential of a nanovector for identification,monitoring,targeting,and post-treatment response analysis.Nanovectors of superparamagnetic iron oxide nanoparticles(SPION)are of tremendous significance in cancer therapy because of their inherited high surface area,high reactivity,biocompatibility,superior contrast,and magnetic and photo-inducibility properties.In addition to a brief introduction,we summarize various progressive aspects of nanomagnets pertaining to their production with an emphasis on sustainable biomimetic approaches.Post-synthesis particulate and surface alterations in terms of pharmaco-affinity,liquid accessibility,and biocompatibility to facilitate cancer therapy are highlighted.SPION parameters including particle contrast,core-fusions,surface area,reactivity,photosensitivity,photodynamics,and photothermal properties,which facilitate diverse cancer diagnostics,are discussed.We also elaborate on the concept of magnetism to selectively focus chemotherapeutics on tumors,cell sorting,purification of bio-entities,and elimination of toxins.Finally,while addressing the toxicity of nanomaterials,the advent of ultrasmall nanomagnets as a healthier alternative with superior properties and compatible cellular in-teractions is reviewed.In summary,these discussions spotlight the versatility and integration of multi-tasking nanomagnets and ultrasmall nanomagnets for diverse cancer theragnostics.
