The change of catecholamines and oxidative stress index in obstructive sleep apnea hypopnea syndrome with hypertension patients and the correlation with blood pressure
10.3760/cma.j.cn115455-20210406-00488
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征伴发高血压患者血清儿茶酚抑素、氧化应激指标变化及其与血压的相关性
- Author:
Jinling ZHOU
1
;
Hongxia HE
;
Huilin CHEN
;
Qingyong GONG
;
Ming JIN
Author Information
1. 荆门市第一人民医院呼吸与危重症医学科，荆门 448000
- Keywords:
Sleep apnea, obstructive;
Hypertension, pulmonary;
Catecholamines;
Oxidative stress;
Correlation
- From:
Chinese Journal of Postgraduates of Medicine
2022;45(10):930-933
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of serum catecholamines (CST) and oxidative stress index in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) with hypertension and the correlation with blood pressure.Methods:Total of 100 OSAHS patients admitted to Jingmen No.1 People′s Hospital from February 2018 to August 2020 were selected. According to whether patients combined with hypertension, they were divided into OSAHS group (54 cases) and OSAHS combined with hypertension group (46 cases). The changes of serum CST and oxidative stress index in the two groups were compared and analyzed the correlation of blood pressure and CST and oxidative stress index.Results:The level of myeloperoxidase(MPO) in the OSAHS combined with hypertension group was higher than that in the OSAHS group: (41.67 ± 3.02) U/L vs. (39.11 ± 2.65) U/L; the levels of catalase (CAT) and CST in the OSAHS combined with hypertension group were higher than those in the OSAHS group: (11.47 ± 2.54) kU/L vs. (15.88 ± 2.31) kU/L, (23.63 ± 4.38) ng/L vs. (28.61 ± 5.42) ng/L, there were statistically differences ( P<0.05). The levels of respiratory disturbance index, lowest oxygen saturation, triacylglycerol, total cholesterol, low density lipoprotein cholesterin, high density lipoproteincholesterol, epinephrine, noradrenaline in the two groups had no significant differences ( P>0.05). Spearman correlation analysis showed that the systolic pressure and diastolic pressure had positive correlation with MPO ( P<0.05), and had negative correlation with CAT and CST ( P<0.05). Conclusions:The serum CST and CAT are down-regulated in patients with OSAHS with hypertension, and serum MPO is up-regulated. Oxidative stress may be related to OSAHS with hypertension.
