The risk factors for hemophagocytic syndrome in childhood Epstein-Barr virus-associated infectious mononucleosis
10.3760/cma.j.cn115455-20210818-01048
- VernacularTitle:EB病毒感染相关传染性单核细胞增多症进展为嗜血细胞综合征的危险因素
- Author:
Yuanyuan HUANG
1
;
Yuxuan WANG
;
Hailong HE
;
Shaoyan HU
;
Lin WAN
;
Jun HUA
;
Lingjun KONG
Author Information
1. 苏州大学附属儿童医院血液科，苏州 215000
- Keywords:
Herpesvirus 4, human;
Infectious mononucleosis;
Hemophagocytic syndrome;
Risk factors
- From:
Chinese Journal of Postgraduates of Medicine
2022;45(7):613-617
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the risk factors for hemophagocytic syndrome (HPS) in childhood Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM).Methods:From January 2013 to December 2017, the medical charts of all children who were diagnosed with EBV-associated IM and HPS in Children′s Hospital of Soochow University were analyzed retrospectively. Statistical analyses were performed using SPSS version 22.0.Results:A total of 316 IM and 59 HPS were enrolled. The age was (4.26 ± 2.95) years old with a male-to-female ratio of 1.2∶1. In addition to the diagnostic criteria of HPS, there were significantly lower rates of fever >10 d, hepatomegaly, jaundice, alanine aminotransferase >500 U/L, aspartate aminotransferase >500 U/L, LDH >1 000 U/L, C-reactive protein >50 mg/L and hypoalbuminemia in children with EBV-associated IM compared to those with HPS, and the differences were statistically significant ( P<0.05). Multivariate Logistic regression analysis showed that fever >10 d, eyelid edema, lymphadenopathy and purulent tonsils were independent predictors of HPS in children with EBV-associated IM ( P<0.05). Hepatomegaly and fever >10 d were risk factors ( OR = 16.079 and 12.138, 95% CI 2.788 to 92.744 and 2.878 to 51.180). Eyelid edema, lymphadenopathy and purulent tonsils were protective factors ( OR = 0.087, 0.006 and 0.031; 95% CI 0.010 to 0.723, 0.001 to 0.058 and 0.007 to 0.146). Conclusions:Hepatomegaly and fever >10 d are the risk factors for hemophagocytic syndrome in childhood EBV-associated infectious mononucleosis.
