Research progress on regulation of lncRNA in age-related ophthalmopathy

VernacularTitle:LncRNA在年龄相关性眼病中的调控作用研究进展
Author: Tianyu CHENG ¹ ; Huaijin GUAN
Author Information

1. 上海交通大学附属第六人民医院眼科，上海　200233
Keywords: Long non-coding RNA; Age-related macular degeneration; Age-related cataract
From: Chinese Journal of Experimental Ophthalmology 2022;40(10):992-995
CountryChina
Language:Chinese
Abstract: Long non-coding RNA (lncRNA) is a class of transcripts longer than 200 nucleotides, which do not have the function of coding proteins.Widely involved in the progress of various human diseases, lncRNA has become a new research hotspot and the regulatory role of it has been paid more and more attention.Studies in recent years found that lncRNA is abnormally expressed in age-related macular degeneration (AMD) and age-related cataract (ARC) compared with healthy individuals.LncRNA ZNF503-AS1, BANCR and MEG3 can play important roles in regulating function of retinal pigment epithelial cell, which can lead to the development of AMD.LncRNA MIAT, TUG1 and H19 can have important regulatory effects through competitive binding with microRNAs, thus affecting the occurrence and development of ARC.This article reviewed the research progress of lncRNA in the AMD and ARC related field, revealed the role of different lncRNAs in the diseases, provided a new perspective for elucidating the mechanism of the diseases and found a new biomarker for the diagnosis and treatment of the diseases.