Research of immunoregulation effects of regulatory T cells in dry eye disease
10.3760/cma.j.cn115989-20190618-00268
- VernacularTitle:调节性T细胞在干眼中的免疫调控作用相关研究
- Author:
Huifeng WANG
1
;
Qingguo RUAN
;
Lixin XIE
Author Information
1. 山东第一医科大学附属眼科研究所 山东第一医科大学附属青岛眼科医院，青岛 266071
- Keywords:
Regulatory T cell;
Regulatory/immunology;
Dry eye;
Inflammation/immunology;
Immunoregulation
- From:
Chinese Journal of Experimental Ophthalmology
2022;40(8):771-774
- CountryChina
- Language:Chinese
-
Abstract:
Dry eye disease is a multifactorial disease affecting the ocular surface, lacrimal glands and meibomian glands.Its incidence is gradually increasing and tends to occur in the younger.Its main features are ocular surface inflammation caused by tear film instability and high osmotic pressure of tears.Moreover, there is a vicious circle between inflammation and ocular surface damage.Immune-related inflammatory responses play a key role in this process.Regulatory T cell (Treg) is a subset of T cells with immunoregulatory functions, which are closely related to the occurrence and development of dry eye, and can inhibit the inflammation of dry eyes by acting on antigen-presenting cells and T helper cell (Th)1/Th17.Recent studies have shown that Treg in dry eye is abnormal in number or function and closely related to the risk factors of dry eye such as age and gender.In addition, by increasing the number of Tregs and promoting their differentiation to alleviate inflammatory response can provide new treatment strategies in dry eye.The correlation between Treg and dry eye and its related research in the pathogenesis and treatment of dry eye were reviewed in this article.
