Clinical features and drug resistance profile of neonatal sepsis caused by different species of Klebsiella
10.3760/cma.j.issn.2096-2932.2022.06.007
- VernacularTitle:不同类型新生儿克雷伯菌败血症的临床特征和耐药性分析
- Author:
Xudong YAN
1
;
Lin YANG
;
Weiyuan WU
;
Yueming PENG
;
Zhaoxia ZHANG
;
Benqing WU
Author Information
1. 深圳市人民医院新生儿科，深圳 518020
- Keywords:
Neonatal sepsis;
Klebsiella pneumoniae;
Klebsiella quasipneumoniae;
Drug resistance
- From:Chinese Journal of Neonatology
2022;37(6):515-519
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical features and drug resistance profile of neonatal sepsis caused by different species of Klebsiella.Methods:From January 2009 to December 2018, cryopreserved Klebsiella strains from blood culture of neonatal sepsis cases in NICU of our hospital were reactivated. Molecular identification and antimicrobial susceptibility tests were performed. Clinical features, laboratory tests, drug resistance profile and prognosis of these patients were analyzed retrospectively.Results:A total of 29 strains of Klebsiella were reactivated. Molecular identification assigned 22 cases (75.9%) into Klebsiella pneumoniae (Kpn) group and 7 cases (24.1%) into Klebsiella quasipneumoniae (Kqu) group. Gestational age and birth weight of Kpn group were higher than Kqu group [(33.1±3.2) weeks vs. (30.6±0.9) weeks, (1 847±677) g vs. (1 416±121) g] ( P<0.05). Abdominal distension was more common in Kqu group than Kpn group [42.9% (3/7) vs. 4.5% (1/22), P<0.05]. No significant differences existed in the laboratory tests including white blood cell count, platelet count, hypersensitive C-reactive protein and procalcitonin between the two groups ( P>0.05). Kpn was 100.0% sensitive to Cefazolin-Tazobactam and Amikacinto and less sensitive to Imipenem and Cefperazone-Sulbactam, Meropenem and Ertapenem. Kqu was generally more sensitive than Kpn and the sensitivity of Kqu to Imipenem was 100.0%. No significant differences existed of the prognosis between the two groups ( P>0.05). Conclusions:Kpn is the main pathogen of neonatal Klebsiella sepsis. Kqu sepsis is more common in neonates with smaller gestational age and lower birth weight. Abdominal distention is common presenting symptom in Kpn sepsis and sensitive antibiotics should be used early.
