Clinical analysis of 7 cases of community-acquired Novel Coronavirus Omicron variant infection in neonates
10.3760/cma.j.issn.2096-2932.2022.05.006
- VernacularTitle:新生儿社区获得性新型冠状病毒奥密克戎变异株感染7例临床分析
- Author:
Liqing XU
1
;
Qing CAO
;
Biao LIU
;
Yiwei CHEN
;
Xiuxia YE
;
Jun BU
;
Fei BEI
Author Information
1. 上海交通大学医学院附属上海儿童医学中心新生儿科，上海 200127
- Keywords:
Omicron;
Novel coronavirus;
Community infection;
Infant, newborn
- From:Chinese Journal of Neonatology
2022;37(5):413-417
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical characteristics of neonatal community-acquired Novel Coronavirus (COVID-19) Omicron variant infection.Methods:From March 30 to May 15, 2022, the epidemiological characteristics, clinical manifestations and outcomes of neonatal cases of community-acquired COVID-19 Omicron variant infection admitted to the isolation ward of our hospital were analyzed.Results:A total of 7 neonates infected with community-acquired COVID-19 Omicron variant were treated, including 3 males and 4 females. All of them were term infants with clear epidemiological exposure history. The infection was originated from caregivers of close contact (parents or babysitters). The main clinical symptoms was upper respiratory tract infection, including fever (6 cases), nasal congestion (6 cases), cough (5 cases), runny nose (2 cases), poor appetite (2 cases) and diarrhea (1 case). On admission, no abnormalities were found in blood routine examination and C-reactive protein (CRP). All but one case had normal serum amyloid A (SAA). No obvious abnormalities were found on chest X-ray. All patients were isolated in single-patient rooms after admission. They received standard symptomatic treatment and regular nucleic acid tests. The first negative nucleic acid results came on median 17 d(8~26 d) after the onset of the disease. The patients were discharged after two consecutive (24 h apart) nucleic acid tests with CT value ≥35 and continued health-monitor at home. On discharge, 5 patients had nasal congestion and 2 of them had cough. During the follow-up 4~6 weeks after discharge, all patients gradually recovered without positive nucleic acid results.Conclusions:All 7 neonates with community-acquired COVID-19 Omicron variant infection have epidemiological exposure history. The main clinical symptoms are long-lasting upper respiratory tract infections. It takes a relatively long time for the nucleic acid to turn negative, however, the overall short-term prognosis is good.
