Risk factors of metabolic bone disease associated fracture in very low birth weight infants
10.3760/cma.j.issn.2096-2932.2022.04.004
- VernacularTitle:极低出生体重儿代谢性骨病骨折危险因素分析
- Author:
Shuting CHANG
1
;
Chenchao FU
;
Zhenyu LIAO
;
Weiqing HUANG
;
Xinhui LIU
Author Information
1. 湖南省儿童医院新生儿科，长沙 410007
- Keywords:
Metabolic bone disease;
Infant,premature;
Fracture;
Risk factors;
Alkaline phosphatase
- From:Chinese Journal of Neonatology
2022;37(4):305-309
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors of metabolic bone disease (MBD) associated fracture in very low birth weight premature infants.Methods:From January 2012 to December 2019, premature infants (gestational age <32 weeks, birth weight <1 500 g) were admitted to our hospital and followed-up regularly for 1.5 years (once every month within first 6 months, then once every 3 months). The infants were assigned into two groups according to X-ray diagnosis: the fracture group and the non-fracture group. The clinical data of the two groups were compared and the risk factors of fracture were analyzed.Results:A total of 62 preterm infants with MBD were included in this study, including 11 in the fracture group and 51 in the non-fracture group. The risk factors of MBD associated fracture included intrauterine growth restriction (IUGR), birth weight <1 000 g, gestational age, respiratory support duration and total parenteral nutrition (TPN) duration ( P<0.05). Logistic regression analysis showed that IUGR ( P<0.05, OR=2.159, 95% CI 1.536~2.759) and TPN duration ( P<0.05, OR=1.143, 95% CI 1.042~1.270) were independent risk factors for fracture. Serum alkaline phosphatase (ALP) in the fracture group was significantly higher than the non-fracture group and 25(OH)VitD was significantly lower than the non-fracture group ( P<0.05). Conclusions:IUGR and TPN duration are risk factors for MBD associated fracture in preterm infants. As biochemical markers of bone metabolism, ALP and 25(OH)VitD levels have clinical value predicting MBD associated fracture.
