Research status of abnormal lipid metabolism associated with pancreatic cancer
10.3760/cma.j.cn115610-20220714-00401
- VernacularTitle:胰腺癌相关异常脂质代谢重塑的研究现状
- Author:
Ning MAO
1
;
Zhongchao CAO
;
Zhitao LIN
;
Zijian HUANG
;
Bei SUN
;
Gang WANG
Author Information
1. 哈尔滨医科大学附属第一医院胰胆外科，哈尔滨 150001
- Keywords:
Pancreatic neoplasms;
Lipid metabolism;
Abnormal regulation;
Metabolic reprogramming;
Research status
- From:
Chinese Journal of Digestive Surgery
2022;21(8):1112-1116
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, with the continuous studies on tumor metabonomics, more and more results have shown that changes of metabolism play important roles in the occurrence and development of malignant tumor. Carcinogenic factors can destroy the metabolic balance of human body, induce metabolic reprogramming, and then mediate a variety of biological behaviors to partici-pate in the proliferation and invasion of cancer cells. Lipids provide the body with the necessary energy and essential fatty acids, and a variety of lipid molecules and metabolites are involved in cell signal transduction. Lipid metabolism is an important link in the metabolic system of the body, and the relationship between the occurrence and development of pancreatic cancer and lipid metabo-lism is not clear. The purpose of this paper is to reveal the changes of lipid metabolism in pancreatic cancer, summarize some preclinical studies and clinical trials, and deeply explain the research status of abnormal lipid metabolism associated with pancreatic cancer, so as to provide new ideas for the study of pancreatic cancer pathogenesis and accurate treatment.
