Research progress of gut microbiota in the prevention and treatment of colorectal cancer
10.3760/cma.j.cn115610-20220402-00176
- VernacularTitle:肠道微生态在结直肠癌预防和治疗中的研究进展
- Author:
Ping LAN
1
;
Shengmei YIN
;
Zhen HE
Author Information
1. 中山大学附属第六医院结直肠外科，广州 510655
- Keywords:
Colorectal neoplasms;
Gut microbiota;
Prevention;
Surgery;
Diagnosis;
Treatment
- From:
Chinese Journal of Digestive Surgery
2022;21(6):730-736
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a common malignancy of the digestive tract, and the gut microbiota is closely related to the occurrence and development of colorectal cancer. The intestinal florae mainly change the host intestinal immune environment and affect the function of the intes-tinal barrier by releasing toxins and producing metabolites to participate the occurrence and deve-lopment of colon cancer. The intestinal florae can be used as biomarkers for early screening and prognosis prediction for colorectal cancer. In addition, the intestinal florae can affect the efficacy of chemotherapy, radiotherapy and immunotherapy for colorectal cancer. The authors review the research progress of gut microbiota in occurrence and development, screening, prognosis prediction and treatment of colorectal cancer, and discuss the application prospects of gut microbiota in the prevention and treatment of colorectal cancer.
