Progress of rebalanced hemostasis and transfusion of blood products in pediatric acute liver failure
10.3760/cma.j.issn.1673-4912.2022.09.011
- VernacularTitle:儿童急性肝衰竭的再平衡止血及血液制品输注的相关进展
- Author:
Qianru JIA
1
;
Mei SUN
Author Information
1. 中国医科大学附属盛京医院儿内科，沈阳 110004
- Keywords:
Pediatric acute liver failure;
Rebalanced hemostasis;
Blood transfusion;
Fresh frozen plasma;
Albumin
- From:
Chinese Pediatric Emergency Medicine
2022;29(9):717-720
- CountryChina
- Language:Chinese
-
Abstract:
Pediatric acute liver failure(PALF)is a severe liver damage caused by multiple factors, resulting in severe impairment of hepatic synthesis, excretion, detoxification and biotransformation.It was thought that PALF patients had coagulation disorders that predisposed them to bleeding.Now it is noted that due to the simultaneous reduction of anticoagulant and procoagulant factors, the body is in a state of rebalanced hemostasis.The risk of thrombosis is nearly equal to hemorrhage.Appropriate laboratory tests can better assess the coagulation status of children with PALF and guide appropriate blood product transfusions to improve coagulation and reduce the risk of transfusion-related fluid overload and other adverse prognosis.
