Hematopoietic stem cell transplantation associated thrombotic microangiopathy
10.3760/cma.j.issn.1673-4912.2022.08.002
- VernacularTitle:造血干细胞移植相关血栓性微血管病
- Author:
Xiaowen QIAN
1
;
Xiaowen ZHAI
Author Information
1. 国家儿童医学中心 复旦大学附属儿科医院血液科，上海 201102
- Keywords:
Hematopoietic stem cell transplantation;
Thrombotic microangiopathy
- From:
Chinese Pediatric Emergency Medicine
2022;29(8):577-583
- CountryChina
- Language:Chinese
-
Abstract:
Hematopoietic stem cell transplantation related thrombotic microangiopathy (TA-TMA) is a clinical syndrome characterized by microvascular hemolytic anemia, thrombocytopenia and involvement of end organ.The pathogenesis of TA-TMA involves vascular endothelial cell injury and abnormal activation of complement system.The risk factors include conditioning regimens, graft-versus-host disease, immunosuppressants, infection and HLA compatibility.Timely diagnosis and early initiation of appropriate treatment are essential to prevent multiple organ dysfunction and eventual death.At present, the lack of clinical evidence of TA-TMA has led to the fact that its diagnostic criteria and treatment have not been unified.The diagnosis and treatment suggestions put forward by domestic and foreign experts are intended to help clinicians evaluate potential TA-TMA, establish diagnosis in time, and give reasonable treatment and management.
