The predicting value of amplitude integration electroencephalogram to the long-term neurodevelopmental disorders in neonatal congenital heart disease
10.3760/cma.j.issn.1673-4912.2022.06.011
- VernacularTitle:新生儿期先天性心脏病手术前后振幅整合脑电图预测中长期神经发育障碍的研究
- Author:
Juan GUI
1
;
Yumei LIU
;
Yifei WANG
;
Chen CHEN
;
Bi WANG
Author Information
1. 广东省人民医院 广东省医学科学院NICU，广州 510080
- Keywords:
Congenital heart disease;
Neonates;
Heart surgery;
Amplitude integrated electroencephalogram;
Neurodevelopment disorder
- From:
Chinese Pediatric Emergency Medicine
2022;29(6):457-461
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association between the perioperative amplitude-integrated electroencephalogram(aEEG)of neonates with congenital heart disease(CHD) and their neurodevelopmental outcome at 2 years of age.Methods:Neonates with CHD ( n=32) who were admitted to the neonatal intensive care unit at our hospital were included.All patients had undergone cardiac surgery during the neonatal period and preoperative and postoperative aEEG monitoring.The background pattern, sleep-wake cycle(SWC) pattern and seizure activity (including electrographic seizure activity) were used to quantify cerebral activity related to brain function.Infants with CHD were enrolled prospectively to follow up at 2 years old.Participants were assessed at 2 years old via the Bayley Scale of Infant Development. Results:A total of 32 neonates were enrolled in the study.Compared with average of normal population, psychomotor development index(PDI) of participants decreased significantly ( P<0.05). The mental development index(MDI) of patients with abnormal behavior was significantly lower.The longer length of ICU, longer time of ventilation, and the older age of father were risk factors of lower PDI.The MDI (76.29±23.38) of cases with mild abnormal preoperative background pattern were significantly lower than that with normal background pattern (97.37±22.65)( P=0.039). The PDI (74.00±20.09) of cases with abnormal preoperative background pattern was significantly lower than that (92.12±20.42) with normal preoperative background pattern ( P=0.046). The PDI (85.04±20.384) of cases with immature preoperative SWC were significantly lower than that with the normal preoperative SWC(110.00±16.55) ( P=0.027). Conclusion:Abnormal perioperative background pattern and SWC are markers for neurodevelopment disorder.The perioperative aEEG is a useful bedside tool that helps predict outcomes in infants underwent heart surgery.
