Depression and Quality of Life in Patients with Systemic Lupus Erythematosus.
10.4078/jrd.2015.22.6.346
- Author:
Sung Hae CHANG
1
;
Ja Hyun CHO
;
Na Hee SHIN
;
Hye Jin OH
;
Byoong Yong CHOI
;
Myeong Jae YOON
;
Eun Young LEE
;
Eun Bong LEE
;
Yun Jong LEE
;
Tae Jin LEE
;
Bong Jin HAHM
;
Young Wook SONG
Author Information
1. Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
- Publication Type:Original Article
- Keywords:
Systemic lupus erythematosus;
Depression;
Quality of life;
Brain-derived neurotrophic factor;
Vitamin D
- MeSH:
Brain-Derived Neurotrophic Factor;
Depression*;
Enzyme-Linked Immunosorbent Assay;
Epidemiologic Studies;
Humans;
Lupus Erythematosus, Systemic*;
Marital Status;
Prevalence;
Quality of Life*;
Self Care;
Vitamin D
- From:Journal of Rheumatic Diseases
2015;22(6):346-355
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The objective of this study is to examine the prevalence of depression and its related factors including quality of life, brain-derived neurotrophic factor (BDNF), and vitamin D in patients with systemic lupus erythematosus (SLE). METHODS: Depression was assessed using the center for epidemiologic studies depression (CES-D) scale. Disease activity, disease-related organ damage, the EuroQol-5 dimensions (EQ-5D), sociodemographic features, and laboratory tests including serum vitamin D level were surveyed. Serum BDNF was measured using an enzyme-linked immunosorbent assay. RESULTS: Depression was observed in 22.8% of 180 SLE patients (n=41). Patients with marital status of single/divorced/separated/widowed, a higher patient global assessment (PGA) score, and extreme pain/discomfort showed significant association with depression. The EQ-5D index showed negative correlation with CES-D score (r=-0.56, p<0.05). In each EQ-5D dimension, depression showed significant association with moderate to severe problems in self-care and usual activities, and extreme pain/discomfort. Serum BDNF levels were not associated with depression (p=0.75) but associated with SLE disease activity index (SLEDAI; r=-0.21, p<0.05). Serum vitamin D levels were not associated with depression (p=0.60) but showed negative correlation with SLEDAI (r=-0.23, p<0.05) and mean glucocorticoid dose over the previous 3 months (r=-0.21, p<0.05) after adjustment for use of vitamin D supplement. CONCLUSION: Depression was prevalent in patients with SLE and was associated with low quality of life, and a higher PGA but not with SLEDAI. Serum BDNF and vitamin D levels were not associated with depression but showed snegative correlation with SLEDAI.
