Longitudinal study of symptoms during chemotherapy in adults with newly diagnosed acute leukemia
10.3760/cma.j.cn211501-20210401-00972
- VernacularTitle:成年人急性白血病初诊患者化疗期间症状的纵向变化研究
- Author:
Yanxin YE
1
;
Xixi YIN
;
Ya YU
;
Suting LIU
;
Huiqun ZHONG
;
Lili ZHANG
Author Information
1. 南方医科大学护理学院，广州 510515
- Keywords:
Longitudinal study;
Adult;
Acute leukemia;
Symptom severity
- From:
Chinese Journal of Practical Nursing
2022;38(17):1292-1297
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the incidence, severity and the change trajectory of symptoms in adult patients with acute leukemia during treatment, so as to provide a reference for clinical medical staff to conduct specific symptom screening and management.Methods:From March 2017 to August 2018, 69 patients who were newly diagnosed with acute leukemia at the Nanfang Hospital of Southern Medical University were conveniently selected. The Memory Symptom Assessment Scale was used to investigate the patients before chemotherapy (T1), after the first chemotherapy (T2), after the second to third chemotherapy (T3) and after the fourth to fifth chemotherapy (T4).Results:The severity score of psychological symptoms in adult patients with acute leukemia at T1, T2, T3, and T4 were 1.00(0.58, 1.42), 1.00(0.83, 1.67), 0.67(0.33, 1.00) and 0.67(0.33, 1.00). The severity score of physical symptoms at T1, T2, T3, and T4 were 0.50(0.21, 0.83), 1.00(0.54, 1.33), 0.75(0.58, 1.17) and 0.92(0.63, 1.08), respectively. The score difference was statistically significant ( H = 28.34, 27.14, both P<0.01) at different time points. The score of physical symptoms reached a peak at T2. In the psychological dimension, the severity and incidence of energy deficiency were higher in T1-T4. Conclusions:Adult acute leukemia patients have different focal symptoms in different treatment stages. Clinical medical staff should provide effective and personalized nursing intervention for patients in different treatment stages.
