Case report of allergic bronchopulmonary aspergillosis with hemoptysis in a child with cystic fibrosis
10.3760/cma.j.cn101070-20220216-00167
- VernacularTitle:儿童囊性纤维化并反复变应性支气管肺曲霉病伴咯血1例
- Author:
Liwei GAO
1
;
Ju YIN
;
Anxia JIAO
;
Yan GUO
;
Baoping XU
;
Kunling SHEN
Author Information
1. 国家儿童医学中心，国家呼吸系统疾病临床医学研究中心，首都医科大学附属北京儿童医院呼吸一科，北京 100045
- Keywords:
Cystic fibrosis;
Hemoptysis;
Allergic bronchopulmonary aspergillosis;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(22):1714-1717
- CountryChina
- Language:Chinese
-
Abstract:
The clinical data of a cystic fibrosis (CF) child with allergic bronchopulmonary aspergillosis (ABPA) and hemoptysis in the Department of Respiratory Disease Ⅰ, Beijing Children′s Hospital, Capital Medical University in May 2021 were retrospectively analyzed.Meanwhile, relevant literature was reviewed to analyze the clinical characteristics, diagnosis and treatment of CF patients with ABPA.This patient was a 15 years and 4 months old boy and complained of recurrent cough with sputum.The test showed increased blood eosinophils, total serum IgE higher than 500 IU/mL, positive aspergillus fumigatus specific IgE and IgG antibodies.Chest CT revealed central bronchiectasis and high-density mucus thrombus, and the patient was initially diagnosed with ABPA.Further examinations suggested the sweat chloride concentration was 89 mmol/L, and the genetic results showed a compound heterozygous mutation of CFTR (c.2909G>A from his father, c.3310G>T from his mother). Then, he was diagnosed with CF complicated with ABPA and treated with glucocorticoid and antifungal therapy.The disease was repeated after drug withdrawal.Due to hemoptysis, the right upper lobe lobectomy was performed.Unfortunately, ABPA occurred again 2 years later.The child is being followed up at present.CF is a rare monogenetic disease with poor prognosis.It is difficult to treat CF patients with ABPA and the disease repeats easily.Early identification and treatment will improve the prognosis.
