Nebulization of intravenous Tobramycin for treatment of Pseudomonas aeruginosa in children with cystic fibrosis
10.3760/cma.j.cn101070-20220201-00122
- VernacularTitle:雾化吸入妥布霉素注射液治疗囊性纤维化患儿铜绿假单胞菌感染
- Author:
Jiehua CHEN
1
;
Zhichuan LI
;
Zhiwei LU
;
Yanmin BAO
;
Wenjian WANG
;
Yuejie ZHENG
Author Information
1. 深圳市儿童医院呼吸科，深圳 518038
- Keywords:
Cystic fibrosis;
Pseudomonas aeruginosa;
Injectable Tobramycin;
Nebulizing;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(22):1709-1713
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the feasibility of nebulizing injectable Tobramycin for the treatment of Pseudomonas aeruginosa (Pa) in pediatric cystic fibrosis (CF) patients. Methods:The clinical data of 3 CF children with Pa infection who were treated by nebulizing injectable Tobramycin in Shenzhen Children′s Hospital from September 2017 to March 2021 were retrospectively analyzed.The efficacy and safety were explored.The nebulized injectable Tobramycin (160 mg/dose) was given twice daily after airway clearance.After one-month treatment course, oral Ciprofloxacin would be given [30 mg/(kg·d)] to patients for another 1 month if Pa was still positive in repeat sputum cultures.Results:There were 2 males and 1 female in 3 cases recruited.The youngest patient was 1-year-old when receiving Tobramycin treatment.After airway clearance and inhalation of injectable Tobramycin, all had improvements in respiratory symptoms and chest CT scan.Two cases took additional oral Ciprofloxacin as Pa was still positive after the 1-month treatment course of Tobramycin.Pa turned to negative in all 3 cases after treatment for 3 months to 1.5 years.Besides, after treatment all the 3 patients had normal liver and renal functions, and normal hearing in multiple follow ups.One patient had a normal brainstem auditory evoked potential in the reexamination.Conclusions:Nebulizing injectable Tobramycin would be a reasonable alternative to inhaled Tobramycin solution for treating pediatric CF patients with Pa in view of the present condition in mainland China.However, it is still worth further study and discussion.
