Application of the emm cluster typing system in related studies of Group A Streptococcus
10.3760/cma.j.cn101070-20210513-00528
- VernacularTitle:emm簇分组系统在A族链球菌相关研究中的应用
- Author:
Waiwai GAO
1
;
Dingle YU
;
Wenjian WANG
Author Information
1. 中国医科大学深圳市儿童医院呼吸科，深圳 518038
- Keywords:
Group A Streptococcus;
emm cluster typing;
emm typing;
M protein
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(21):1677-1680
- CountryChina
- Language:Chinese
-
Abstract:
Group A Streptococcus (GAS) is one of the most important pathogens leading to children deaths all over the world.Bacterial typing is the commonest approach to analyzing the epidemiological characteristics of pathogenic microorganisms.The emm typing is frequently adopted to study GAS.The emm cluster typing is a recently proposed typing method based on the amino acid sequence homology of M proteins and the ability to bind to the host serum protein.This typing system has been extensively used for epidemiological investigation, strain selection and vaccine deve-lopment in foreign countries.However, it has not been applied in China yet. emm typing is based on a small variable region of emm genes, while the emm cluster typing system defines GAS types according to nearly intact sequences of emm genes.Besides, the emm cluster grouping system is acquired directly by emm typing comparison, so it is simple and feasible.Furthermore, the emm cluster typing can provide more information regarding the functional and structural properties of M proteins in different emm types of GAS.In this review, the methods, principles and applications of the emm cluster typing system in GAS research were summarized, in order to promote its application in China.
