Regulatory mechanism for the proliferation and differentiation of growth plates
10.3760/cma.j.cn101070-20210625-00727
- VernacularTitle:生长板成熟与分化调控机制概述
- Author:
Shumin ZHAN
1
;
Wei PENG
;
Guanping DONG
;
Junfen FU
Author Information
1. 浙江大学医学院附属儿童医院内分泌科，国家儿童健康与疾病临床医学研究中心，国家儿童区域医疗中心，杭州 310052
- Keywords:
Growth plate;
Cartilage differentiation;
Endocrine;
Transcription factor
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(20):1596-1600
- CountryChina
- Language:Chinese
-
Abstract:
The growth plate (cartilage tissue) is the key to bone development and linear growth.However, as the adolescence proceeds, the proliferation capacity of the growth plate will be continuously consumed, and finally the growth plate will be closed.A variety of regulatory factors control chondrocyte proliferation and differentiation through different mechanisms.Endocrine regulators (including growth hormone, insulin-like growth factor, thyroxine, sex hormone, glucocorticoid, etc.) and transcription factors play an important role in regulating the development of growth plates through systematic modulation.In addition, such local regulatory factors as Indian hedgehog protein, parathyroid hormone-related peptide, bone morphogenetic protein and fibroblast growth factor also regulate the development of the growth plate.In this paper, the regulatory mechanism for chondrocyte proliferation and differentiation was summarized.
