Primary amoebic meningoencephalitis in children: a case report and literature review
10.3760/cma.j.cn101070-20220328-00327
- VernacularTitle:儿童原发性阿米巴脑膜脑炎1例并文献复习
- Author:
Meigui HAN
1
;
Zhiyuan WANG
;
Shujun LI
;
Ziming HAN
;
Qian HUANG
;
Xiaojuan ZHU
;
Fangmin ZHANG
Author Information
1. 新乡医学院第一附属医院儿科，卫辉 453100
- Keywords:
Primary amoebic meningoencephalitis;
Naegleria fowleri;
Literature review;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(19):1501-1503
- CountryChina
- Language:Chinese
-
Abstract:
A case of primary amoebic meningoencephalitis (PAM) treated in the First Affiliated Hospital of Xinxiang Medical University in March 6, 2022 was reported.The proband was a 14-year-old boy, who was admitted to the hospital because of " fever, headache and vomiting for 2 days" . Metagenomic next-generation sequencing (mNGS) was consequently conducted to examine the pathogens in cerebrospinal fluid.Naegleria infection was detected, so the child was diagnosed with PAM.The disease developed rapidly, and the patient died 29 hours after admission.In the paper, a total of 13 studies were reviewed, and 15 children with PAM were reported.Of the reported cases, only 1 case survived, 14 cases died.PAM had a low incidence, a dangerous condition, and high mortality.Most cases were diagnosed by autopsy or pathogen diagnosis in cerebrospinal fluid.This case is confirmed by mNGS of pathogens, and it is rarely reported at home and abroad.
