Case report of pediatric systemic lupus erythematosus combined with hypophosphatasia

VernacularTitle:儿童系统性红斑狼疮并低磷酸酶血症1例
Author: Mengzhen ZHANG ¹ ; Wei PAN ; Xin TIAN
Author Information

1. 吉林大学第二医院儿科，长春　130041
Keywords: Child; Systemic lupus erythematosus; Hypophosphatasia
From: Chinese Journal of Applied Clinical Pediatrics 2022;37(18):1417-1419
CountryChina
Language:Chinese
Abstract: The clinical data of a child with systemic lupus erythematosus (SLE) and hypophosphatasia (HPP) admitted to the Department of Pediatrics, the Second Hospital of Jilin University in December 2015 were retrospectively analyzed.The patient was a 10-year-old boy who was hospitalized because of fever and facial rashes in the past 4 days.He had a history of HPP for 7 years.His clinical manifestations included skeletal and dental dysplasia, oral ulcers, buccal erythema and renal lesions.Laboratory examination showed a low level of serum alkaline phosphatase, whole blood cell count decreased, antinuclear antibody(ANA) 1∶1 000, anti-double strand DNA antibodies positive, anticardiolipin antibodies positive, complement 3 (C 3) and C 4 decreased.Therefore, he was diagnosed with SLE.After glucocorticoid, immunosuppressant and symptomatic treatment, the child′s condition improved and he discharged from the hospital.He was followed up regularly, and died 2 years after the diagnosis of SLE.SLE complicated with HPP is extremely rare in clinical practice, and the symptoms may overlap.Hence these two diseases should be differentiated.