Progress of the Nod-like receptor family pyrin domain-containing protein 12 in autoinflammatory diseases
10.3760/cma.j.cn101070-20210520-00561
- VernacularTitle:Nod样受体家族含pyrin结构域蛋白12在自身炎症性疾病中的研究进展
- Author:
Yue LI
1
;
Huawei MAO
Author Information
1. 重庆医科大学附属儿童医院风湿免疫科，儿童发育疾病研究教育部重点实验室，国家儿童健康与疾病临床医学研究中心，儿童感染免疫重庆市重点实验室，重庆 400014
- Keywords:
Nod-like receptor family pyrin domain-containing protein 12;
Nuclear factor Kappa-B;
Autoinflammatory diseases;
Familial cold autoinflammatory syndrome t
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(16):1268-1272
- CountryChina
- Language:Chinese
-
Abstract:
The Nod-like receptor family pyrin domain-containing protein 12(NLRP12), a newly discovered member of the Nod-like receptor family, is one of the important pattern recognition receptors.It recognizes a variety of pathogens, initiates downstream immune responses, and participates in the regulation of multiple inflammatory responses.NLRP12 is related to the occurrence and progression of inflammatory diseases.In this review, the structure and function of NLRP12 as well as NLRP12-associated autoinflammatory diseases were discussed, so as to provide new insights for the understanding, exploration and treatment of NLRP12-associated autoinflammatory diseases.
