Advances of microglia in the development of epilepsy
10.3760/cma.j.cn101070-20201216-01901
- VernacularTitle:小胶质细胞在癫痫发展中的研究进展
- Author:
Deying LIU
1
;
Chunhui HU
;
Wei YIN
;
Zhisheng LIU
Author Information
1. 华中科技大学同济医学院附属武汉儿童医院风湿免疫科，武汉 430016
- Keywords:
Epilepsy;
Seizures;
Microglia
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(15):1193-1196
- CountryChina
- Language:Chinese
-
Abstract:
The synchronous abnormal discharge of neurons leads to epileptic seizures.However, in addition to neurons, microglia, as the main immune cells in the brain, plays an important role in the development and maintenance of neural circuits.Microglia is involved in early epileptic seizures, which can be mediated by increasing inflammatory cytokines and chemokines.Microglia can regulate the abnormal neurogenesis after epileptic seizures, promote the death of neurons after seizures, and cause neurodegeneration.Moreover, it can also affect synaptic pruning after seizures, eliminate synapses by phagocytosis or stripping, destroy the balance between synaptic excitation and inhibition, and aggravate seizures.Microglia plays an important role in the development of epilepsy.However, whether microglia participates in the occurrence of epilepsy still needs to be further studied.
