Skin photosensitivity induced by Voriconazole in children with ABCB1 rs1045642 T/T genotype: a case report and literature review
10.3760/cma.j.cn101070-20210309-00281
- VernacularTitle:ABCB1 rs1045642 T/T基因型儿童应用伏立康唑致皮肤光敏反应1例并文献复习
- Author:
Yue ZHANG
1
;
Xiaolin XU
;
Tongxin HAN
;
Jiasen XIE
;
Xiaoling WANG
;
Huawei MAO
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院免疫科，北京 100045
- Keywords:
Voriconazole;
Photosensitivity;
ABCB1 gene;
Pharmacokinetics;
Pharmacogenomics
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(15):1181-1183
- CountryChina
- Language:Chinese
-
Abstract:
The clinical data of a child with ABCB1 rs1045642 T/T genotype and skin photosensitivity induced by Voriconazole were analyzed retrospectively in Beijing Children′s Hospital, Capital Medical University in September 2020.Literature was reviewed to discuss the relationship between ABCB1 genetic polymorphism and Voriconazole pharmacokinetics.The patient was a 6.8-year-old boy, who was diagnosed with primary immunodeficiency disease.Long-term oral Voriconazole was administered for prevention and treatment of fungal infections.Skin photodistributed erythema and pigmentation occurred about 3-4 weeks after treatment.The skin lesions were significantly alleviated about 1 month after the withdrawal of Voriconazole.Gene test showed ABCB1 rs1045642 T/T in the patient.Some studies reported that ABCB1 rs1045642 T/T genotype reduced the clearance rate of Voriconazole.Monitoring such adverse reaction of Voriconazole in clinical practice is important. ABCB1 gene polymorphism is possible to correlate with the pharmacokinetics and adverse reactions of Voriconazole.However, further large-scale clinical studies are warranted to verify it.
