Efficacy of the Troponin T Rapid Assay Kit in Early Diagnosis of Acute Myocardial Infarction.
10.4070/kcj.1995.25.6.1116
- Author:
Bon Kwon KU
;
Han Soo KIM
;
So Yeon CHOI
;
Young Woong HWANG
;
Joon Han SHIN
;
Seung Jea TAHK
;
Byung il CHOI
- Publication Type:Original Article
- Keywords:
Acute myocardial infarction;
Troponin T;
Troponin T rapid assay kit
- MeSH:
Diagnosis;
Diagnostic Errors;
Early Diagnosis*;
Emergency Service, Hospital;
Humans;
Mortality;
Muscle, Skeletal;
Myocardial Infarction*;
Sensitivity and Specificity;
Shock, Septic;
Troponin T*;
Troponin*
- From:Korean Circulation Journal
1995;25(6):1116-1121
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: In the diagnosis of acute myocardial infarction, measurement of CK-MB is widely used as an enzyme test, but it needs special instruments, lacks specificity in the presence of concomitant skeletal muscle injuries, and has narrow diagnostic time window. Cardiac specific troponin T-a new marker for the diagnosis of myocardial injury-is now available. Besides the quantitative assay, rapid qualitative asay is also possible with the development of rapid assay Kit. We studied about the efficacy of the Troponin T rapid assay Kit in early doagnosis of actue myocardial infarction in the emergency room. METHODS: Total Ck, Ck-MB, LDH and serum troponin T activities were determined when the patients arrived at the emergency room and at the same time Troponin T rapid assay kit test was done. Final diagnosis was made through the serial measurement of CK, CK-MB and LDH. Diagnostic efficacy of each rest was evaluated. RESULTS: Overall diagnostic sensitivity and specificity of Troponin T rapid assay kit were 0.97 and 0.91. When evaluated only with the initial results, Troponin T rapid assay kit showed sensitivity 0.87, specificity 0.97, serum troponin T 0.75, 0.92, and Ck-Mb 0.81,0.95. In one patient who was finally diagnosed as a septic shock, Ck-MB was elevated but serum troponin T was not and Troponin T rapid assay kit test showed negative result. CONCLUSION: Troponin T rapid assay kit test seems to show nearly the same sensitivity and specificity in diagnosis of acute myocardial infarction compared to CK-MB. This test can be done simply and easily in a short time. Thus, with the use of this test, morbidity, mortality and economic loss due to misdiagnosis and delay of diagnosis of myocardial infarction might be reduced.
