In vitro antibacterial activity of pediatric Faropenem sodium against respiratory tract pathogens in children
10.3760/cma.j.cn101070-20210823-01015
- VernacularTitle:小儿法罗培南钠对儿童呼吸道常见致病菌的体外抗菌活性研究
- Author:
Limin DONG
1
;
Lin YUAN
;
Wei GAO
;
Qing WANG
;
Wei SHI
;
Yue LI
;
Dan YU
;
Qinghong MENG
;
Gang LIU
;
Kaihu YAO
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院，北京市儿科研究所皮肤疾病研究室，国家呼吸系统疾病临床医学研究中心，教育部儿科重大疾病研究重点实验室，北京 100045
- Keywords:
Faropenem sodium;
Respiratory tract pathogens;
Streptococcus pneumoniae;
Haemophilus influenza;
Klebsiella pneumoniae;
Moraxella catarrhalis;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(14):1086-1092
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the antibacterial activity of pediatric Faropenem sodium against common pathogens isolated from children′s respiratory tract in vitro, and to provide reference for its clinical research and application. Methods:Retrospective analysis.The minimum inhibitory concentration (MIC) of Faropenem sodium, Merope-nem, Imipenem and other antibiotics was determined by the agar dilution method.A total of 156 strains of Streptococcus pneumoniae [including 32 strains of Penicillin-susceptible Streptococcus pneumoniae (PSSP), 28 strains of Penicillin-intermediate Streptococcus pneumoniae (PISP) and 96 strains of Penicillin-resistant Streptococcus pneumoniae (PRSP)], 98 strains of Haemophilus influenza, 173 strains of Klebsiella pneumoniae, and 55 strains of Moraxella catarrhali clinical isolates were used.MIC 50, MIC 90 and the accumulative inhibition of the bacteria were investigated. Results:The MIC of Faropenem sodium against all the Streptococcus pneumoniae strains ranged from 0.010-2.000 mg/L.There was no difference in the MIC distribution of Faropenem sodium against PSSP, PISP and PRSP, and the MIC 90 value was all 1.000 mg/L.Faropenem sodium inhibited all the Haemophilus influenza strains at concentrations ranging from 0.030-8.000 mg/L.There was no difference in the MIC distribution of Faropenem sodium against Haemophilus influenza with or without β-lactamase and Ampicillin resistance.The MIC 90 value was all 4.000 mg/L.Ho-wever, the MIC of Faropenem sodium against Klebsiella pneumoniae ranged from 0.250 to above 32.000 mg/L, and both MIC 50 and MIC 90 were greater than 32.000 mg/L.Faropenem sodium inhibited all the Moraxella catarrhalis strains at concentrations ranging from 0.030-2.000 mg/L, with MIC 50 being 0.500 mg/L and MIC 90 being 1.000 mg/L. Conclusions:Antimicrobial susceptibility testing results in vitro demonstrate that pediatric Faropenem sodium has satisfactory antibacterial activities against Streptococcus pneumoniae, Haemophilus influenza, and Moraxella catarrhalis, but comparatively weak antibacterial activities against Klebsiella pneumoniae.
