Research on the clinical diagnostic value of joint test of RBP, CYSC, and urinary ALB/Cr in early diabetes nephropathy
10.3760/cma.j.cn.115807-20220309-00053
- VernacularTitle:血清RBP、CYSC和尿ALB/Cr联合检测对早期糖尿病肾病的诊断价值
- Author:
Li YUE
1
;
Nannan WANG
;
Qun LU
;
Zhengyin WANG
Author Information
1. 太和县人民医院皖南医学院附属太和医院检验科, 阜阳 236600
- Keywords:
Retinol-binding protein;
Cystatin C;
Urinary albumin/creatinine ratio;
Diabetes nephropathy;
Type 2 diabetes mellitus;
Diabetes mellitus
- From:
Chinese Journal of Endocrine Surgery
2022;16(3):283-286
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical diagnostic value of joint test of retinol-binding protein (RBP), cystatin C (CYSC) and urinary (albumin/creatinine ratio, ALB/Cr) ALB/Cr in early diabetes nephropathy.Methods:Data of 50 early diabetic nephropathy patients (EDN group) from Jan. 2020 to Jun. 2021 in our hospital, another 50 pure type 2 diabetic patients (T2DM group), and 50 healthy subjects (control group) were compared and analysed. RBP, CYSC and urinary ALB/Cr were tested for the 3 groups. Then the clinical diagnostic value between single index test and joint test for the early diabetes nephropathy were compared.Results:Group EDN had higher RBP, CYSC and urinary ALB/Cr [ (114.66±0.56) mg/L, (2.64±0.33) mg/L, (351.81±15.48) ] mg/g than group T2DM [ (83.58±0.83) mg/L, (1.41±0.29) mg/L, (113.65±12.55) mg/g] and control group[ (38.61±0.66) mg/L, (0.53±0.26) mg/L, (16.36±5.61) mg/g]. The difference was statistically significant ( P<0.05). The specificity and sensitivity of early diabetes nephropathy were 95.38% and 96.21%, both higher than single index test. Conclusion:The combined detection of serum RBP, CYSC and urine ALB/Cr has certain reference value for the clinical diagnosis of early diabetic nephropathy.
