Correlation between saliva glucose and blood glucose levels by ion chromatography
10.3760/cma.j.cn.115807-20210421-00125
- VernacularTitle:离子色谱法研究唾液葡萄糖与血糖水平的相关性
- Author:
Qian DOU
1
;
Chun XU
;
Qing DAI
;
Boyu ZHU
;
Haijian GUO
;
Xinhua XIAO
Author Information
1. 国家纳米科学中心，中国科学院卓越中心，中国科学院纳米光子材料与器件重点实验室，北京 100190
- Keywords:
Diabetes mellitus;
Non-invasive blood glucose monitoring;
Saliva glucose;
Ion chromatography
- From:
Chinese Journal of Endocrine Surgery
2022;16(3):269-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between saliva glucose and blood glucose level by measuring the concentration of saliva with high-precision ion chromatograph, and further to provide the clinical data for saliva glucose as an auxiliary index of blood glucose monitoring.Methods:A total of 268 subjects with normal glucose metabolism (NGT) and diabetes mellitus (DM) were enrolled and fasting venous blood and saliva samples were collected at the same time. The levels of saliva glucose, blood glucose and glycosylated hemoglobin (HbA1c) were measured by ion chromatograph, automatic biochemical analyzer and glycosylated hemoglobin analyzer, respectively. Methods of Kruskal-Wallis H test was used for comparison between groups, and the Spearman correlation was used for correlation analysis. Results:The mean values of blood glucose, saliva glucose and HbA1c in the DM group are all higher than those in the NGT group, and the differences are all statistically significant ( P<0.05). Saliva glucose cut-off points are set at 10, 15, 20 and 25 mg/L, respectively. When the saliva glucose concentration is greater than or equal to the above cut-off points, the saliva glucose level are positively correlated with the blood glucose level ( r=0.321, 0.379, 0.509 and 0.428, respectively, P<0.05) . Conclusion:The level of saliva glucose in DM is significantly higher than that in NGT. When the concentration of saliva glucose is greater than 20 mg/ L, there is a significant positive correlation between saliva glucose and blood glucose, and the max correlation coefficient r is 0.509.
