Clinical characteristics of sepsis-associated acute kidney injury: a retrospective analysis of 197 cases
10.3760/cma.j.issn.1671-0282.2022.10.012
- VernacularTitle:脓毒症相关性急性肾损伤的临床特点分析：197例回顾性分析
- Author:
Yirui GAO
1
;
Qiang LI
;
Ruifeng ZENG
;
Suyi YANG
;
Guocong CHEN
;
Jun LI
Author Information
1. 广州中医药大学，广州 510006
- Keywords:
Sepsis;
Acute kidney injury;
Transient;
persistent;
Urinary tract infection;
Advanced age;
Urea Nitrogen;
Mortality
- From:
Chinese Journal of Emergency Medicine
2022;31(10):1368-1372
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To retrospectively analyze the incidence, mortality, clinical characteristics and related factors of transient and persistent acute kidney injury in patients with sepsis in emergency department.Methods:Patients with sepsis ≥ 18 years old hospitalized in the Emergency Department of Guangdong Provincial Hospital of Chinese Medicine from June 2018 to May 2020 were selected as the research objects. According to the renal function injury at admission and the renal function recovery at 48 h after admission, patients with sepsis were divided into three groups: non-S-AKI group, transient S-AKI group, and persistent S-AKI group.Results:A total of 197 patients with sepsis were included, including 95 patients with non-S-AKI, 39 patients with transient S-AKI and 63 patients with persistent S-AKI. The mortality in the persistent S-AKI group was significantly higher than that in the non-S-AKI group (36.5% vs. 17.9%, P<0.05), but there was no significant difference between the transient S-AKI group and non-S-AKI group (20.5% vs. 17.9%, P>0.05). Multiple categorical disordered Logistic regression analysis showed that urea was associated with transient S-AKI ( OR=1.440, 95% CI: 1.235-1.680), and age ( OR=1.049, 95% CI: 1.008-1.092), urea ( OR=1.440, 95% CI: 1.277-1.733), and infection site in non-urinary tract ( OR=0.149, 95% CI: 0.050-0.448) were associated with persistent S-AKI. Conclusions:The incidence of persistent S-AKI is higher than that of transient S-AKI. Persistent S-AKI is related to the prognosis of patients with sepsis, and the mortality rate is higher, while transient S-AKI has no significant relationship. The urea of patients with S-AKI would increase significantly, and advanced age and urinary tract infection are related factors for the occurrence of persistent S-AKI. For patients with sepsis with such factors, attention should be paid to early protection of renal function to prevent persistent S-AKI.
