Effect of the timing of peripancreatic fluid drainage on prognosis in patients with severe acute pancreatitis: a two-center clinical retrospective study
10.3760/cma.j.issn.1671-0282.2022.06.023
- VernacularTitle:重症急性胰腺炎患者胰周引流时机对预后的影响：一项双中心临床回顾性研究
- Author:
Yumin HE
1
;
Xiaoping WANG
;
Fei SHAO
;
Ziren TANG
;
Shen ZHAO
Author Information
1. 福建省立医院急诊科，福建医科大学省立临床医学院,福州 350001
- Keywords:
Severe acute pancreatitis;
Peripancreatic drainage;
SOFA score;
APACHE Ⅱscore;
Propensity score matching;
Survival analysis
- From:
Chinese Journal of Emergency Medicine
2022;31(6):822-827
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of the timing of peripancreatic drainage on the survival outcome of patients with severe acute pancreatitis (SAP).Methods:This retrospective study included 271 patients with SAP admitted to two tertiary hospitals from January 2015 to December 2019. The Acute Physiology and Chronic Health EvaluationⅡ score (APACHEⅡ), Sequential Organ Failure Assessment score (SOFA), computed tomography (CT) grade, peripancreatic drainage situations, and survival outcome of patients were recorded. Patients were divided into the early and non-early peripancreatic catheter drainage groups (EPCD and non-EPCD). The data were analyzed using the Cox proportional hazard model for propensity score matching (PSM) and stratification.Results:After PSM, the 30-day and 90-day risk of death between the EPCD and non-EPCD groups were significantly different (0.134, 95% CI: 0.029-0.576, P=0.007; 0.166, 95% CI: 0.044-0.631, P=0.008, respectively). Furthermore, stratified analysis revealed significant differences in 30-day and 90-day risk of death between the EPCD and non-EPCD groups when the SOFA score was≥4 or the APACHEⅡ score was ≥8. Conclusions:For patients with SAP with SOFA score ≥4 or APACHEⅡ score≥8, early peripancreatic drainage can reduce the risk of death, but CT grading is not helpful for the decision-making of drainage timing in patients with SAP.
