Effect of serum uric acid on recurrent stroke in patients with acute cerebral infarction.
10.3760/cma.j.issn.1671-0282.2022.06.022
- VernacularTitle:急性脑梗死患者血尿酸水平对再发脑卒中的影响
- Author:
Hongyan LI
1
;
Lijie QIN
;
Jingyu LI
;
Longan WANG
Author Information
1. 河南省人民医院急诊科，郑州 450003
- Keywords:
Acute cerebral infarction;
Serum uric acid;
Cerebrovascular mortality;
Recurrent stroke;
Cardiovascular disease;
hs-CRP;
NIHSS score;
Follow-up
- From:
Chinese Journal of Emergency Medicine
2022;31(6):817-821
- CountryChina
- Language:Chinese
-
Abstract:
Objective:investigate the effect of serum uric acid (SUA) on long-term cerebrovascular mortality and recurrent stroke in patients with acute cerebral infarction.Methods:A total of 132 patients from the same center were enrolled in this study. The patients were divided into three groups according to the quartile level of SUA: group 1 (SUA < 442 μmol/L, n= 69) , group 2 (SUA 442-620 μmol/L, n=35) and group 3 (SUA > 620 μmol/L, n= 28). SUA, blood urea nitrogen, serum creatinine, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total cholesterol, triglyceride and hypersensitive c-reactive protein (hs-CRP) were measured in the three groups, the National Institutes of Health Stroke Scale (NIHSS) score was determined on the day of admission, and the patients were followed up until December 31, 2020. The differences of recurrent stroke and cerebrovascular mortality in the three groups were analyzed. Results:Sixty-nine patients were selected in group 1, 35 in group 2 and 28 in group 3. Patients in group 2 and group 3 were younger, and had higher hs-CRP levels, higher SUA levels, and higher rates of recurrent stroke and cerebrovascular mortality, and the differences were statistically significant (all P<0.05). Cerebrovascular mortality (log-rank χ2 =13.19, P=0.001) and recurrent stroke (log-rank χ2 =10.30, P=0.006) were significantly increased in group 3. The risk of recurrent stroke in group 3 was 3.55 times higher than that in group 1. Conclusions:The risks of long-term cerebrovascular mortality and recurrent stroke were significantly increased in patients of acute cerebral infarction with elevated serum uric acid.
