Necroptosis in inflammatory bowel disease: A potential effective target
10.11817/j.issn.1672-7347.2022.210501
- VernacularTitle:炎症性肠病中的坏死性凋亡::一个潜在的治疗靶点
- Author:
Xiuyan LONG
1
;
Ningxin ZHU
;
Jianing QIU
;
Xiaoyu YU
;
Xixian RUAN
;
Xiaoyan WANG
;
Li TIAN
Author Information
1. 中南大学湘雅三医院消化内科,长沙 410013
- Keywords:
inflammatory bowel disease;
necroptosis;
receptor interacting protein kinase 1;
receptor interacting protein kinase 3;
mixed lineage kinase domain-like protein
- From:
Journal of Central South University(Medical Sciences)
2022;47(9):1289-1298
- CountryChina
- Language:Chinese
-
Abstract:
The morbidity of inflammatory bowel diseases (IBD) is rising rapidly but no curative therapies to prevent its recurrence. Cell death is crucial to maintaining homeostasis. Necroptosis is a newly identified programmed cell death and its roles played in IBD need to be explored. Necroptosis is mediated by receptor interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL), which resulted in cell swelling, plasma membrane rupture, intracellular content leaking, and eventually cell death as well as the promotion of inflammation. Studies have found that inhibiting necroptosis alleviated IBD in animal models and IBD patients with an increased level of necroptosis in inflammatory tissues, indicating that necroptosis is related to the pathogenesis of IBD. However, due to the complexity in regulation of necroptosis and the involvement of multiple functions of relevant signaling molecules, the specific mechanism remains elusive. Necroptosis may play a vital regulatory role in the pathogenesis of IBD, which provides a new idea and method for further exploring the therapeutic target of IBD.
