Bronchoalveolar Cellularity and IL-8 Levels in Patients with Post-measles Wheezing.
- Author:
Da Eun JUNG
1
;
Byeong Eui KIM
;
Ju Young CHUNG
;
Jeong Yeon KIM
;
Sang Hyuk MA
;
Chang Keun KIM
Author Information
1. Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea. kim.chang@mayo.edu
- Publication Type:Original Article
- Keywords:
Measles;
Wheezing;
Bronchoalveolar lavage;
Neutrophils;
IL-8
- MeSH:
Bronchiectasis;
Bronchoalveolar Lavage;
Bronchoscopy;
Cell Count;
Enzyme-Linked Immunosorbent Assay;
Hospital Records;
Humans;
Infant;
Interleukin-8*;
Measles;
Neutrophils;
Perfusion;
Respiratory Sounds*;
Retrospective Studies
- From:Journal of the Korean Pediatric Society
2003;46(8):763-768
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was conducted to investigate the pulmonary cellular profiles and IL-8 levels in patients with post-measles wheezing. METHODS: Twelve previously healthy infants with a minimum of three episodes of wheezing after measles pneumonia(Measles wheezing, median age, 1.3 years) were recruited by a retrospective examination of hospital records. They underwent bronchoalveolar lavage(BAL) with flexible bronchoscopy, and high-resolution computed tomography(HRCT) with a mean six(1-15) months interval. Comparisons were made with seven normal controls(Control, median age: 7.4 years). BAL cell counts and differentials were determined. IL-8 levels also were measured by ELISA. RESULTS: The BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the Measles wheezing group(median 16.0%) compared to the control group(median 3.8%)(P<0.01). IL-8 levels were markedly increased in the Measles wheezing group(mean+/-SD, 512.7+/-324.0 pg/mL) compared to the control group(41.7+/-67.7 pg/mL)(P<0.01). Furthermore, IL-8 levels correlated significantly(r=0.816, P=0.001) with neutrophil percentages in BAL fluids in the Measles wheezing group. Abnormal HRCT findings were mosaic perfusion, bronchiectasis, bronchial wall thickening, and decreased vascularity. CONCLUSION: These results suggest that pulmonary neutrophils and IL-8 may play an important role in the pathogenesis of the post-measles wheezing.
