Optimization of molding process of Jinpuju Qingrelishi Granules by Response Surface Methodology
10.3760/cma.j.cn115398-20201128-00237
- VernacularTitle:效应面法优化金蒲菊清热利湿颗粒成型工艺
- Author:
Weiwei CHEN
1
;
Jincheng HUANG
;
Jinxiang LI
;
Ying QIN
;
Yuyang LI
;
Xiangcen LIU
;
Xinggui TAN
Author Information
1. 广西中医药大学药学院，南宁 530200
- Keywords:
Granule;
Jinpuju Qingrelishi Granules;
Molding process;
Response surface methodology;
Technology improving (TCD)
- From:
International Journal of Traditional Chinese Medicine
2022;44(11):1273-1277
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the best molding process of Jinpuju Qingrelishi Granules.Methods:Based on the single factor test, the relative density of clear ointment and the amount of diluent (dextrin∶lactose=2∶1) are used as investigating factors, and the overall evaluation of the molding rate and angle of repose overall desirability (OD) is used as the evaluation index. The effect surface method is used to optimize the best molding process of Jinpuju Qingrelishi Granules.Results:The best molding process conditions: the relative density of the clear paste is 1.20 (60 ℃) and the amount of diluent is 3 times that of the clear paste. After mixing the clear paste and diluent, make soft material, pass through a 14-mesh sieve to granulate, dry in an oven (55 ℃) for 1 hour, and sizing to obtain. The molding rates of the three batches of verification test granules were 93.73%, 93.03%, 95.59%, respectively, the predicted OD value was 0.928, the verification value was 0.936, and the deviation from the predicted value was -0.86%.Conclusion:The molding process of this experiment is stable and reliable, with good repeatability, which can provide a reference for the follow-up research of Jinpuju Qingrelishi Granules.
