Clinical study on Xiefei Tongfu Decoction combined with conventional western medicine therapy for the patients with pulmonary pseudomonas aeruginosa infection after brain trauma and syndrome of phlegm-heat and bowel-repletion
10.3760/cma.j.cn115398-20211008-00035
- VernacularTitle:泻肺通腑汤结合西医常规疗法治疗脑外伤后肺部铜绿假单胞菌感染痰热腑实证临床研究
- Author:
Yuting TAN
1
;
Chuan LIU
;
Ming ZHOU
Author Information
1. 简阳市中医医院检验科，成都 641400
- Keywords:
Brain injuries;
Pseudomonas aeruginosa;
Bacterial infections;
Syndrome of phlegm-heat and bowel-repletion;
Xiefei Tongfu Decoction;
Etimicin sulfate;
Merope
- From:
International Journal of Traditional Chinese Medicine
2022;44(9):982-986
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effects of Xiefei Tongfu Decoction on syndrome of phlegm-heat and bowel-repletion in patients with pulmonary pseudomonas aeruginosa infection after brain trauma.Methods:A total of 90 patients with pulmonary pseudomonas aeruginosa infection after traumatic brain injury received treatment in our hospital from August 2018 to May 2021 were selected and randomly divided into control group ( n=45) and study group ( n=45) by the random digital table method. The control group was treated with conventional western medicine, and the study group was treated with Xiefei Tongfu decoction and conventional western medicine. The TCM syndrome scores, inflammatory factor levels, like C-reactive protein (CRP), interleukin-6 (IL-6), white blood cell count (WBC), and lung function indexes, like forced vital capacity (FVC), forced expiratory volume rate in the first second (FEV1), expiratory volume percentage in forced vital capacity (FEV1/FVC) were compared between the two groups before and after treatment. The clinical effect and adverse events of the two groups were compared. Results:The total effective rate was 91.11% (41/45) in the study group and 73.33% (33/45) in the control group, with a statistically significant difference between the two groups ( χ2=4.97, P=0.027). After treatment, the scores of dizziness, headache, forgetfulness, insomnia and total scores in the study group were significantly lower than those in the control group ( t values were 9.65, 9.81, 8.62, 9.11, 9.34, all Ps<0.01). After treatment, CRP [(95.66±11.67) mg/L vs. (107.82±12.99) mg/L, t=4.67], IL-6 [(25.16±6.46) ng/L vs. (33.45±7.33) ng/L, t=5.69], WBC [(9.35±2.02)×10 9/L vs. (13.12±2.18)×10 9/L, t=8.51] in the control group were significantly lower than those in the control group ( P<0.01). After treatment, the FEV1 [(2.34±0.31) L vs. (1.92±0.33) L, t=6.22], FVC [(3.45±0.46) L vs. (2.96±0.37) L, t=5.57], FEV1/FVC [(68.82±8.64)% vs. (64.86±9.56)%, t=2.18] in the control group significantly higher than those in the control group ( P<0.01 or P<0.05), and no serious adverse events occurred in any groups, and there was no significant difference between the two groups ( χ2=1.39, P=0.238). Conclusion:The Xiefei Tongfu Decoction has a significant effect on patients with pulmonary pseudomonas aeruginosa infection after brain trauma, which can improve symptoms, relieve inflammatory response and enhance lung function with safety.
