Effect of acupuncture on learning and memory ability and hippocampal Ngb expression in rats with vascular cognitive impairment
10.3760/cma.j.cn115398-20210922-00289
- VernacularTitle:针刺对血管性认知障碍大鼠学习记忆能力和海马Ngb表达的影响
- Author:
Peijia HU
1
;
Hongliang CHENG
;
Tao YANG
;
Xing LIU
;
Qinghai LI
;
Hanyu ZHANG
Author Information
1. 安徽中医药大学第二附属医院内分泌科，合肥 230061
- Keywords:
Acupuncture;
Brain ischemia;
Cognition disorders;
Neuroglobin;
Rats
- From:
International Journal of Traditional Chinese Medicine
2022;44(6):645-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the effect of acupuncture on learning and memory ability and the expression of neuroglobin (Ngb) of the hippocampus of vascular cognitive impaired (VCI) rats.Methods:VCI rats model was established by repeated ligation of the carotid arteries of the two sides to induce ischemia-reperfusion injury. The successful modeled rats were divided into acupuncture group and a model group according to the random number table method, with 12 rats in each group, and 12 rats were selected as the normal group. The rats in the acupuncture group received acupuncture at "Baihui", "Fengfu" and "Yongquan", 10 times as a course of treatment, a total of 3 courses, and stop acupuncture treatment for 2 days during the courses of treatment. Neurobehavioral scores were measured on the 3rd day after the intervention. Morris water maze was conducted to detect the learning and memory ability of the rats in each group, and Western blot was used to detect the expression of Ngb in the hippocampus of the rats.Results:Compared with the model group, the behavioral score of the acupuncture group decreased after intervention ( P<0.05), the escape latency was significantly shortened ( P<0.05), the number of crossing platforms was increased ( P<0.05), and the hippocampal Ngb (1.18±0.06 vs.0.98±0.04) was significantly increased ( P<0.05). Conclusion:Acupuncture at "Baihui", "Fengfu" and "Yongquan" could promote the expression of Ngb in the hippocampus of rats and improve the learning and memory ability of VCI rats.
